Angio-suppressive triterpenoids from Ardisia cf. elliptica (subgenus Tinus) on duck (Anas platyrynchos L.) chorioallantoic membrane.
10.1016/S1875-5364(13)60039-4
- Author:
Dennis D RAGA
1
;
Annabelle A HERRERA
;
Consolacion Y RAGASA
Author Information
1. Biology Department, School of Science and Engineering, Ateneo de Manila University, Loyola Heights, Quezon City 1108, Philippines. consolacion.ragasa@dlsu.edu.ph
- Publication Type:Journal Article
- MeSH:
Angiogenesis Inhibitors;
chemistry;
pharmacology;
Animals;
Ardisia;
chemistry;
Chorioallantoic Membrane;
blood supply;
drug effects;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Ducks;
Plant Leaves;
chemistry;
Triterpenes;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2013;11(2):128-138
- CountryChina
- Language:English
-
Abstract:
The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes (1a-1c) at ratios of 2 : 2 : 1, 2 : 2 : 3 and 1 : 1 : 1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM). All three ratios were found to be effective in restricting inter-capillary length, while 1a-1c (2 : 2 : 1) was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of 1a-1c (2 : 2 : 1).
