Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities.
10.1016/S1875-5364(15)30070-4
- Author:
Li-Na GUO
1
;
Rui ZHANG
2
;
Xue-Ying GUO
2
;
Tao CUI
1
;
Wei DONG
1
;
Jin-Hai HUO
2
;
Wei-Ming WANG
3
,
4
Author Information
1. School of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
2. Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China.
3. Institute of Traditional Chinese Medicine, Heilongjiang Traditional Chinese Medicine Academy of Sciences, Harbin 110016, China. Electronic address: zyyjy@
4. com.
- Publication Type:Journal Article
- Keywords:
Anticancer activity;
Juglans mandshurica;
Juglanstetralone A;
Juglanstetralone B;
Walnut husk
- MeSH:
Antineoplastic Agents, Phytogenic;
isolation & purification;
pharmacology;
therapeutic use;
Carcinoma;
drug therapy;
Cell Line, Tumor;
Humans;
Juglans;
chemistry;
Naphthols;
isolation & purification;
pharmacology;
therapeutic use;
Nuts;
chemistry;
Phytotherapy;
Plant Extracts;
chemistry;
pharmacology;
therapeutic use;
Stomach Neoplasms;
drug therapy
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(9):707-710
- CountryChina
- Language:English
-
Abstract:
Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).
