Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production.
10.1016/S1875-5364(18)30039-6
- Author:
Qiang FU
1
,
2
;
Min YANG
3
;
Yu MA
3
;
Jiang CHEN
3
;
Hai-Mei YUAN
3
Author Information
1. College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, China. Electronic address: peter028@
2. com.
3. College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, China.
- Publication Type:Journal Article
- Keywords:
Clematis mandshurica;
Mandshunosides F–I;
NO production;
Triterpene saponins
- MeSH:
Animals;
Clematis;
chemistry;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Macrophages;
drug effects;
metabolism;
Mice;
Molecular Structure;
Nitric Oxide;
metabolism;
RAW 264.7 Cells;
Rhizome;
chemistry;
Saponins;
chemistry;
isolation & purification;
pharmacology;
Triterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(2):131-138
- CountryChina
- Language:English
-
Abstract:
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin (3-9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%- 64.6% at 50 μmol·L, whereas monodesmosidic saponins with a free carboxyl group at C-28 (1 and 2) showed potent inhibitory activities with IC values being 12.7 and 8.3 μmol·L, respectively.
