Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity.
10.1016/S1875-5364(18)30066-9
- Author:
Wei ZHANG
1
;
Chun-Zhen WU
2
;
Si-Yang FAN
3
,
4
Author Information
1. Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China; Innovation Center of Traditional Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
2. Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China; Sinopharm Health Industry Research Co., Ltd., Shanghai 201203, China.
3. Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China; Innovation Center of Traditional Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai 201203, China. Electronic address: max_121@
4. com.
- Publication Type:Journal Article
- Keywords:
Caffeoylquinate;
Compositae;
Flavonoid;
Gnaphalium affine;
Xanthine oxidase inhibition
- MeSH:
Adenine;
analogs & derivatives;
chemistry;
isolation & purification;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Enzyme Activation;
drug effects;
Flavonoids;
chemistry;
isolation & purification;
Gnaphalium;
chemistry;
Gout Suppressants;
chemistry;
isolation & purification;
pharmacology;
Hydroxybenzoates;
chemistry;
isolation & purification;
Molecular Structure;
Nuclear Magnetic Resonance, Biomolecular;
Phytochemicals;
chemistry;
isolation & purification;
pharmacology;
Plant Components, Aerial;
chemistry;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Quinic Acid;
analogs & derivatives;
chemistry;
isolation & purification;
Xanthine Oxidase;
antagonists & inhibitors
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(5):347-353
- CountryChina
- Language:English
-
Abstract:
Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (-) ethyl 1, 4-di-O-caffeoylquinate (1) and (-) methyl 1, 4-di-O-caffeoylquinate (2), together with 35 known compounds (3-37). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 11.94 μmol·L) and 2 (IC 15.04 μmol·L) showed a good inhibitory activity. The current results supported the medical use of the plant.
