Antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
10.1016/S1875-5364(14)60030-3
- Author:
Afsar SHAIK
1
;
Rupesh S KANHERE
2
;
Rajaram CUDDAPAH
2
;
Kumar S NELSON
2
;
Prasanth Reddy VARA
2
;
Saisaran SIBYALA
2
Author Information
1. Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India. Electronic address: afsarsk_14@yahoo.com.
2. Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
- Publication Type:Journal Article
- Keywords:
Anti-implantation activity;
Antifertility activity;
Artemisia vulgaris;
Estrogenic activity
- MeSH:
Animals;
Artemisia;
Contraceptive Agents;
pharmacology;
Embryo Implantation;
drug effects;
Female;
Fertility;
drug effects;
Organ Size;
Ovariectomy;
Phytoestrogens;
pharmacology;
Plant Extracts;
pharmacology;
Plant Leaves;
Rats, Wistar;
Uterus;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(3):180-185
- CountryChina
- Language:English
-
Abstract:
AIM:To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
METHOD:The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.
RESULTS:The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.
CONCLUSION:The methanolic plant extract of A. vulgaris has antifertility activity.
