Chemical profiling of Jinqi Jiangtang tablets by HPLC-ESI-Q-TOF/MS.
10.1016/S1875-5364(14)60039-X
- Author:
Shi SUN
1
;
Zhi-Shen XIE
1
;
E-Hu LIU
1
;
Yu-Ting YAN
1
;
Xiao-Jun XU
2
,
3
;
Ping LI
3
,
4
Author Information
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xiaojunxu2000@
3. com.
4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: liping2004@
- Publication Type:Journal Article
- Keywords:
Astragali Radix;
Coptidis Rhizoma;
HPLC-ESI-Q-TOF/MS;
Jinqi Jiangtang tablets;
Lonicerae Japonicae Flos;
Mass spectrometry
- MeSH:
Alkaloids;
analysis;
Astragalus Plant;
Chromatography, High Pressure Liquid;
Coptis;
Drugs, Chinese Herbal;
chemistry;
Flavonoids;
analysis;
Iridoid Glycosides;
analysis;
Lonicera;
Phenols;
analysis;
Saponins;
analysis;
Spectrometry, Mass, Electrospray Ionization;
Tandem Mass Spectrometry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(3):229-240
- CountryChina
- Language:English
-
Abstract:
AIM:To profile the chemical constituents in Jinqi Jiangtang tablets.
METHOD:Based on the chromatographic retention behavior, fragmentation patterns of chemical components, and published literatures, a high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (HPLC-ESI-Q-TOF/MS) method was established to characterize and identify components in Jinqi Jiangtang tablets.
RESULTS:A total of 52 chemical compounds, including eight iridoid glycosides, seven phenolic acids, twelve alkaloids, six flavonoids, and nineteen saponins, were identified in Jinqi Jiangtang tablets.
CONCLUSION:The established method could serve as a powerful tool for structural characterization and quality control of this Chinese herbal preparation.
