A new sesquiterpene lactone from the fruits of Illicium henryi.
10.1016/S1875-5364(14)60074-1
- Author:
Ji-Feng LIU
1
,
2
;
Hui-Juan LI
3
;
Jing-Min ZHANG
4
;
Li-Xia WANG
3
;
Ya-Feng WANG
4
;
Meng-Qi LIU
5
;
Yue-Feng BI
3
;
Yan-Bing ZHANG
3
Author Information
1. School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China. Electronic address: liujf2009y@
2. com.
3. School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China.
4. School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China; Henan Key laboratory for Pharmacology of Liver Disease, Academy of Medical and Pharmaceutical Science, Zhengzhou University, Zhengzhou 450052, China.
5. School of Pharmaceutical Science, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
- Publication Type:Journal Article
- Keywords:
Anti-HBV activity;
Illicium henryi;
Sesquiterpene lactones
- MeSH:
Antiviral Agents;
chemistry;
isolation & purification;
pharmacology;
Fruit;
chemistry;
Hep G2 Cells;
Hepatitis B virus;
drug effects;
Humans;
Illicium;
chemistry;
Molecular Structure;
Plant Extracts;
chemistry;
pharmacology;
Sesquiterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(6):477-480
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents of the fruits of Illicium henryi.
METHOD:Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses.
RESULTS:Seven compounds were obtained and their structures were identified as 10-benzoyl-cycloparvifloralone (1), cycloparvifloralone (2), 2α-hydroxycycloparviforalone (3), henrylactone B (4), merrillianone (5), henrylactone C (6) and 7, 14-ortholactone- 3-hydroxyfloridanolide (7).
CONCLUSION:Compound 1 is a new sesquiterpene lactone. The tested compounds showed weak anti-HBV activities on HBV surface antigen (HBsAg) secretion and HBV e antigen (HBeAg) secretion using Hep G2.2.15 cell line.
