Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats.
10.1016/S1875-5364(14)60077-7
- Author:
Seval DEVELI
1
;
Betül EVRAN
1
;
Esra BETÜL KALAZ
1
;
Necla KOÇAK-TOKER
1
;
Gül Özdemirler ERATA
2
Author Information
1. Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Çapa, 34093, Istanbul, Turkey.
2. Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Çapa, 34093, Istanbul, Turkey. Electronic address: gul_erata@yahoo.com.
- Publication Type:Journal Article
- Keywords:
Binge ethanol;
Liver;
Nigella sativa;
Oxidative stress;
Rats
- MeSH:
Animals;
Disease Models, Animal;
Ethanol;
adverse effects;
Female;
Humans;
Liver;
drug effects;
injuries;
metabolism;
Liver Diseases, Alcoholic;
drug therapy;
enzymology;
etiology;
metabolism;
Malondialdehyde;
metabolism;
Nigella sativa;
chemistry;
Oxidative Stress;
drug effects;
Plant Oils;
administration & dosage;
Protective Agents;
administration & dosage;
Rats;
Rats, Sprague-Dawley;
Superoxide Dismutase;
metabolism;
Transaminases;
blood
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(7):495-499
- CountryChina
- Language:English
-
Abstract:
AIM:Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats.
METHOD:Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg(-1), orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg(-1)) every 12 h three times (binge model).
RESULTS:Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg(-1)) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings.
CONCLUSION:NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration.
