Anti-hypercholesterolemic effect of Pistacia lentiscus fatty oil in egg yolk-fed rabbits: a comparative study with simvastatin.
10.1016/S1875-5364(14)60086-8
- Author:
Zouhir DJERROU
1
Author Information
1. Institute of Veterinary Sciences, Pharmacology & Toxicology Laboratory, Mentouri Constantine University, Algeria. Electronic address: Zouhir21265@yahoo.fr.
- Publication Type:Journal Article
- Keywords:
Anti-hperlipidemic activity;
Fatty oil;
Pistacia lentiscus;
Rabbits
- MeSH:
Animals;
Anticholesteremic Agents;
pharmacology;
therapeutic use;
Cholesterol;
blood;
Cholesterol, HDL;
blood;
Cholesterol, LDL;
blood;
Diet;
Egg Yolk;
Female;
Fruit;
Hyperlipidemias;
blood;
drug therapy;
etiology;
Lipids;
blood;
Phytotherapy;
Pistacia;
Plant Oils;
pharmacology;
therapeutic use;
Rabbits;
Simvastatin;
pharmacology;
therapeutic use;
Triglycerides;
blood
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(8):561-566
- CountryChina
- Language:English
-
Abstract:
AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet.
METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperlipidemic control (EY) group receiving standard diet and gavaged daily with egg yolk (10 mL), (c) hyperlipidemic + PLFO (EY + PLFO) group receiving as the EY group and treated daily with PLFO (2 mL/kg BW, (d) hyperlipidemic + simvastatin (EY + SVS) group receiving as the EY group and treated once daily with 2.5 mg/kg BW of simvastatin. At the end of the six-week experimental period, the lipidemic profiles of the different groups were investigated.
RESULTS:In the EY group, the egg yolk resulted in a significant increase of total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, and the LDL-C/HDL-C ratio. Both the EY + PLFO and EY + SVS groups, when compared to the EY group, showed a significant decrease of TC, TG, LDL-C, and the LDL-C/HDL-C ratio. However, with respect to HDL-C the differences were not significant. The TGs were significantly lower (P < 0.001) in the simvastatin-treated group when compared to rabbits treated in the PLFO group.
CONCLUSION:The study concludes that P. lentiscus fatty oil (PLFO) possesses anti-hyperlipidemic properties at least in reducing total cholesterol, LDL-cholesterol and triglycerides.
