Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration.
10.1016/S1875-5364(14)60113-8
- Author:
Sunil K JAISWAL
1
;
Mukesh K DUBEY
2
;
Sanjib DAS
2
;
Ch V RAO
3
Author Information
1. Department of Pharmacy, Rameshwaram Institutes of Technology & Management, Lucknow 226020, Uttar Pradesh, India.
2. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India.
3. Pharmacognosy & Ethnopharmacology Div., National Botanical Research Institute (CSIR), Rana Pratap Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address: sunil_pharmachem90@yahoo.co.in.
- Publication Type:Journal Article
- Keywords:
Anti-ulcer activity;
Antioxidant enzymes;
Barleria prionitis;
HPTLC;
Iridoid
- MeSH:
Acanthaceae;
chemistry;
Animals;
Anti-Ulcer Agents;
administration & dosage;
Disease Models, Animal;
Humans;
Iridoids;
administration & dosage;
Male;
Plant Extracts;
administration & dosage;
Protective Agents;
administration & dosage;
Rats;
Rats, Wistar;
Stomach Ulcer;
drug therapy
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(10):738-744
- CountryChina
- Language:English
-
Abstract:
AIM:To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves (BPE) against different gastric ulcer models in rats.
METHOD:The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress (CRS), and pylorus ligation (PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model.
RESULTS:BPE showed a dose-dependent ulcer protective effect in PL (18.67%-66.26% protection), aspirin (24.65%-63.25% protection), CRS (20.77%-59.42% protection), and EtOH (16.93%-77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO (P < 0.01-0.001), SOD (P < 0.01-0.001), and an increase in CAT (P < 0.01-0.001), activity in the CRS-induced model.
CONCLUSION:The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential.
