Siderochelins with anti-mycobacterial activity from Amycolatopsis sp. LZ149.
10.1016/S1875-5364(15)60009-7
- Author:
Chun-Hua LU
1
;
Fang-Wen YE
2
;
Yue-Mao SHEN
3
Author Information
1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: ahua0966@sdu.edu.cn.
2. School of Life Sciences, Xiamen University, Xiamen 361005, china.
3. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; School of Life Sciences, Xiamen University, Xiamen 361005, china.
- Publication Type:Journal Article
- Keywords:
Amycolatopsis sp. LZ149;
Bioassay-guided;
Mycobacterium smegmatis;
Siderochelin;
X-ray single crystal diffraction
- MeSH:
Actinobacteria;
chemistry;
Anti-Infective Agents;
pharmacology;
Dihydropyridines;
isolation & purification;
Magnetic Resonance Spectroscopy;
Microbial Sensitivity Tests;
Molecular Structure;
Mycobacterium smegmatis;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(1):69-72
- CountryChina
- Language:English
-
Abstract:
Three new compounds, namely siderochelins D (2), E (3), and F (4), together with one known siderochelin A (1), were isolated from Amycolatopsis sp. LZ149 and elucidated by spectroscopic analyses including1D- and 2D-NMR and X-ray single crystal diffraction. Compounds 1-3 showed antibacterial activity against Mycobacterium smegmatis.
