Metabolomics coupled with similarity analysis advances the elucidation of the cold/hot properties of traditional Chinese medicines.
10.1016/S1875-5364(17)30091-2
- Author:
Yan JIA
1
;
Zheng-Zheng ZHANG
1
;
Yu-Hai WEI
2
;
Xue-Mei QIN
3
;
Zhen-Yu LI
4
Author Information
1. Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, China; College of Chemistry and Chemical Engineering of Shanxi University, Taiyuan 030006, China.
2. Qinghai Entry-Exit Inspection and Quarantine Bureau, Xining 810000, China.
3. Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, China.
4. Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, China. Electronic address: lizhenyu@sxu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cold/hot property;
Metabolomics;
NMR;
Similarity analysis;
Traditional Chinese medicine
- MeSH:
Animals;
Drugs, Chinese Herbal;
chemistry;
metabolism;
Liver;
chemistry;
drug effects;
metabolism;
Male;
Medicine, Chinese Traditional;
Metabolomics;
Mice;
Mice, Inbred ICR;
Molecular Structure;
Plants, Medicinal;
chemistry;
Serum;
chemistry;
drug effects;
metabolism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(8):631-640
- CountryChina
- Language:English
-
Abstract:
It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine (TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance (NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.
