Analysis and synthesis of the related substances of palbociclib
10.11665/j.issn.1000-5048.20150610
- VernacularTitle:Palbociclib有关物质的分析及合成
- Author:
Duo YUAN
1
;
Xiong ZHU
;
Shijin ZHANG
;
Duo WANG
;
Zhiyu LI
;
Liping SUN
Author Information
1. 中国药科大学药学院
- Publication Type:Journal Article
- Keywords:
palbociclib;
structural identification;
related substances;
synthesis
- From:
Journal of China Pharmaceutical University
2015;46(6):696-699
- CountryChina
- Language:Chinese
-
Abstract:
To strengthen the quality control of palbociclib, three related substances were separated from the bulk drug. These substances were identified as 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido ［2, 3-d］ pyrimidin-7(8H)-one(A), 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridine-2-yl)amino)-6-vinylpyrido ［2, 3-d］ pyrimidin-7(8H)-one(B), tert-butyl4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido ［2, 3-d］ pyrimidin-2-yl)amino)pyridin-3-yl)piperazi-ne-1-carboxylate(C). Based on the structures of the impurities, the possible routes to them were discussed, and their structures were elucidated by 1H NMR and MS.
