Construction and characterization of mitochondria-targeted TPP-PEI-LND
10.11665/j.issn.1000-5048.20150604
- VernacularTitle:线粒体靶向聚合物TPP-PEI-LND的构建及其特性
- Author:
Bingfeng ZHANG
1
;
Hulin JIANG
Author Information
1. 中国药科大学药学院；贵阳中医学院
- Publication Type:Journal Article
- Keywords:
mitochondria-targeted;
polymer;
lonidamine;
triphenylphosphine;
polyethyleneimine
- From:
Journal of China Pharmaceutical University
2015;46(6):659-664
- CountryChina
- Language:Chinese
-
Abstract:
The mitochondria-targeted TPP-PEI-LND was synthesized by mitochondria-targeted ligand triphenylphosphine(TPP)and therapeutic drug lonidamine(LND)conjugated to low molecular weight branched polyethyleneimine(PEI). TPP-PEI-LND was verified using 1H NMR; in vitro release was determined by the dialysis. Besides, the cytotoxicity and mitochondria-targeted potential of TPP-PEI-LND were investigated in HeLa cells. The results showed that TPP-PEI-LND was successfully synthesized and it exhibited the feature of extended-release. Hence, TPP-PEI-LND could deliver LND to mitochondria, resulting in significantly enhanced efficacy of LND.
