Advances in the research of FLT3 inhibitors for acute myeloid leukemia

VernacularTitle:FLT3激酶抑制剂及其在急性髓系白血病治疗领域的研究进展
Author: Tonghui LI ¹ ; Hao GUO ; Tao LU ; Yue WANG ; Shuai LU ; Weifang TANG
Author Information

1. 中国药科大学有机化学教研室
Publication Type:Journal Article
Keywords: FLT3 inhibitor; acute myeloid leukemia; small molecular inhibitor; advances
From: Journal of China Pharmaceutical University 2015;46(2):153-161
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia(AML)is one of the most common acute leukemias in adults. Those patients with FLT3 mutations have a particularly poor prognosis. Recently, the emergence of a variety of targeted inhibitors has shown the capability of suppressing FLT3 signaling in vivo, which provided a new way to treat AML. In this paper, we reviewed those inhibitors based on their structures, which include indolone-related inhibitors, indolocarbazo-related inhibitors, benzimidazole/benzopyrazole-related inhibitors, quinoline/quinoxaline/quinazoline-related inhibitors, tricyclic inhibitors, pyrimidine-related inhibitors and others.