Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis
10.11665/j.issn.1000-5048.20150112
- VernacularTitle:益智仁中二苯基庚烷类化合物的血管生成抑制活性
- Author:
Xiaoping GAO
1
;
Lixiao CHEN
;
Zhiqi YIN
;
Linlin JIANG
;
Qinghua LIN
;
Mingfang HE
Author Information
1. 南京工业大学药学院
- Publication Type:Journal Article
- Keywords:
angiogenesis;
zebrafish;
HUVEC;
curcumin;
diarylheptanoid;
Yakuchinone A;
Yakuchinone B
- From:
Journal of China Pharmaceutical University
2015;46(1):85-88
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the anti-angiogenic activities of two diarylheptanoids, together with a structure analogue, curcumin. The activity and toxicity of these three compounds were compared using transgenic zebrafish as in vivo model and human umbilical vein endothelial cell(HUVEC)as in vitro model. Anti-angiogenic index(AI)was used as the ratio between LC50 and EC50. The results suggested that in both in vitro and in vivo assay, curcumin exerted the most potent anti-angiogenic effect but with lowest toxicity among these compounds; Yakuchinone A was the second potent; Yakuchinone B has the lowest activity but with the highest toxicity in all three compounds. Taken together, curcumin was the best angiogenic inhibitor in these three diarylheptanoids.
