Pharmacokinetic translational research from bench to bedside
10.11665/j.issn.1000-5048.20150105
- VernacularTitle:非临床药代动力学的临床转化研究进展
- Author:
Kun HAO
1
;
Dan YU
;
Guangji WANG
Author Information
1. 中国药科大学药物代谢动力学重点实验室
- Publication Type:Journal Article
- Keywords:
non-clinic;
pharmacokinetics;
bench to bedside
- From:
Journal of China Pharmaceutical University
2015;46(1):50-57
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetic translation from bench to bedside has been an important component in translational research. Based on non-clinical pharmacokinetic research results, scale factor allometric model and physiology- based pharmacokinetic model were used to investigate the translational method of pharmacokinetic parameters from quantitative pharmacology perspective. The method includes the reasonable extrapolation of translation for inter-species and analysis of in vivo-in vitro differences. The pharmacokinetic translation model from bench to bedside will help to optimize clinical administration into simulation study.
