Advances of nano-drug delivery systems overcoming the physiological and pathological barriers of tumor
10.11665/j.issn.1000-5048.20150103
- VernacularTitle:克服肿瘤生理病理屏障的纳米药物递送系统的研究进展
- Author:
Zhigui SU
1
;
Ran MO
;
Can ZHANG
Author Information
1. 中国药科大学江苏省代谢性疾病药物重点实验室
- Publication Type:Journal Article
- Keywords:
nano-drug delivery systems;
physiological and pathological barriers;
tumor microenvironment;
in situ response;
targeted therapy
- From:
Journal of China Pharmaceutical University
2015;46(1):28-39
- CountryChina
- Language:Chinese
-
Abstract:
Nano-drug delivery systems(nano-DDSs)play an important role in targeted cancer therapy. Due to the physiological characteristics of the body and the heterogenicity of tumor, intravenous delivery of anticancer agents carried by nano-DDSs from the injection site to their targeted sites is required to overcome multiple physiological and pathological barriers, including blood, tumor tissue, tumor cell and intracellular transportation. This review surveys emerging strategies for the development of novel nano-DDSs that can conquer the physiological and pathological barriers of tumor, which provides a great potential platform for safe and efficient cancer treatment.
