Advances in the mechanism research of natural products against acute lung injury
10.11665/j.issn.1000-5048.20160404
- VernacularTitle:天然产物防治急性肺损伤的作用机制研究进展
- Author:
Sulan YU
1
;
Xiu YU
;
Junping KOU
Author Information
1. 江苏省中药评价与转化重点实验室，中国药科大学中药复方研究室
- Publication Type:Journal Article
- Keywords:
natural products;
acute lung injury;
pathological characteristics;
signal pathways;
receptors
- From:
Journal of China Pharmaceutical University
2016;47(4):397-403
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury(ALI)is a common critical disease with increasing morbidity and mortality rate in clinic. Its major pathological cause is the inflammation imbalance, which can cause diffuse alveolar and pulmonary vascular endothelial cell injury, lung edema and atelectasis. Many pathways and receptors, such as NF-κB and MAPK signaling pathways, and the adenosine A2A receptors, Toll-like receptors(TLRs), peroxisome proliferator-activated receptor gamma(PPARγ), etc. are involved in ALI. Nowadays, prevention and treatment of ALI with natural products attract more and more attention. This article reviews the advances in the mechanisms research of natural products in recent three years against ALI so as to provide some references and clues for the development of innovative drugs to prevent and treat ALI.
