Recent progress in autophagy and vascular calcification
10.11665/j.issn.1000-5048.20180403
- VernacularTitle:自噬与血管钙化的研究进展
- Author:
Rui YANG
1
;
Yi ZHU
;
Yin WANG
;
Wenqi MA
;
Xin WANG
;
Xiqiong HAN
;
Naifeng LIU
Author Information
1. 中国药科大学基础医学与临床药学学院；山东省千佛山医院药学部
- Publication Type:Journal Article
- Keywords:
autophagy;
vascular calcification;
mechanism;
signal transduction pathway
- From:
Journal of China Pharmaceutical University
2018;49(4):401-406
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a “self-devouring” biological process of the degradation of organelles and proteins by lysosomes in eukaryotic cells. In the past few years, some results revealed that autophagy played an important role in the regulation of vascular calcification. This review summarized the recent studies on autophagy in the process of vascular calcification, and discussed the effects of electrolyte imbalance, matrix vesicle release, oxidative stress, inflammatory reaction of vascular endothelial cells, and lipid metabolism in autophagy. The research progress of β-catenin/AMPK/CREB/Nrf2-ARE/Erα signal transduction pathways in autophagy induction was reviewed.
