Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
- Author:
Mi Jin KIM
1
;
Na young KIM
;
Yun A JUNG
;
Seunghyeong LEE
;
Gwon Soo JUNG
;
Jung Guk KIM
;
In Kyu LEE
;
Sungwoo LEE
;
Yeon Kyung CHOI
;
Keun Gyu PARK
Author Information
- Publication Type:Brief Communication
- From:Diabetes & Metabolism Journal 2020;44(1):186-192
- CountryRepublic of Korea
- Language:English
- Abstract: Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect of evogliptin, a DPP-4 inhibitor, has not been studied. Here, we report the beneficial effects of evogliptin on unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice. Evogliptin attenuated UUO-induced renal atrophy and tubulointerstitial fibrosis. Immunohistochemistry and Western blotting demonstrated that evogliptin treatment inhibits pro-fibrotic gene expressions and extracellular matrix production. In vitro findings showed that the beneficial effects of evogliptin on renal fibrosis are mediated by inhibition of the transforming growth factor-β/Smad3 signaling pathway. The present study demonstrates that evogliptin is protective against UUO-induced renal fibrosis, suggesting that its clinical applications could extend to the treatment of kidney disease of non-diabetic origin.
