The quantitative analysis of MR dynamic contrast-enhangced imaging on efficacy and prognosis of transcatheter arterial chemoembolization on hepatocellular carcinoma
10.3760/cma.j.issn.0253-3766.2017.09.010
- VernacularTitle: 磁共振动态增强技术对肝细胞癌经导管肝动脉化疗栓塞疗效的预测和评估价值
- Author:
Xiaohong MA
1
;
Shuang WANG
1
;
Xinming ZHAO
1
;
Han OUYANG
1
;
Meng WANG
2
;
Yongjian ZHU
1
;
Zheng ZHU
1
;
Chunwu ZHOU
1
Author Information
1. Department of Diagnostic Radiology, National Cancer Center/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
2. Department of epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China
- Publication Type:Clinical Trail
- Keywords:
Magnetic resonance imaging;
Hepatocellular carcinoma;
Dynamic contrast-enhangced;
Efficacy
- From:
Chinese Journal of Oncology
2017;39(9):689-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic value of quantitative parameters of dynamic contrast-enhangced MR (DCE-MR) on short-term efficacy of transcatheter arterial chemoembolization (TACE) on hepatocellular carcinoma(HCC).
Methods:79 patients with HCC underwent non-enhanced MR imaging and DCE on a 3.0T MR scanner before and one month after TACE. The quantitative parameters were measured on the maximal tumor region, including maximal tumor diameter(MTD), ADC, Ktrans, Kep and Ve value before and after TACE. All patients were divided into stable group (36 patients) and progressive group (43 patients) based on follow-up. The quantitative data of the two groups before and after TACE was collected for analysis.
Results:Among the 79 lesions in 79 patients, 21 were located in the left lobe of the liver, 53 in the right lobe of the liver and 5 in the junction area of the hepatic lobe. The maximum tumor diameter (MTD) was 2.2-9.9 cm, the median MTD was 5.1 cm. There were significant differences between progressive group and the stable group in MTD, Ktrans, Kep values of the tumor before TACE (P<0.05). One month after TACE, the MTD, Ktrans, Kep,ΔMTD, ΔKtrans and ΔKep values of the tumor in progressive group were statistically different with the stable group (P<0.05, respectively). For all the patients, the pre-TACE MTD, AFP, Ktrans and Kep values of tumors were statistically different with the post-TACE values (P<0.05).
Conclusion:The quantitative parameters (Ktrans, Kep,ΔKtrans and ΔKep values) of the DCE-MR could predict and evaluate the short-term efficacy of TACE on HCC.
