Oxidative damage effects induced by CdTe quantum dots in mice
10.3760/cma.j.issn.1001-9391.2017.07.003
- VernacularTitle: 碲化镉量子点对小鼠体内氧化损伤的作用
- Author:
Guangyun XIE
1
;
Wei CHEN
;
Quankai WANG
;
Xiurong CHENG
;
Jianning XU
;
Peili HUANG
Author Information
1. National Insititue of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
CdTe;
Quantum dots (QDs);
Mice;
Superoxide dismutose
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(7):487-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate Oxidative damage effects induced by CdTe Quantum Dots (QDs) in mice.
Methods:40 ICR mice were randomly divided into 5 groups: one control group (normal saline) ; four CdTe QDs (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0、0.5、5.0、50.0 and 500.0 nmol/ml respectively) . After 24 h, the mice were decapitated and the blood was collected for serum biochemically indexes、hematology indexes, the activities of SOD、GSH-Px and the concentration of MDA were all detected.
Results:The results showed in the four CdTe QDs exposure groups, the level of CRE、PLT and the concentration of MDA were all significantly lower than those of the control group (P<0.05 or P<0.01) ; the activities GSH-Px in 50.0 and 500.0 nmol/ml CdTe QDs group were significantly higher than those of control group (P<0.01) .
Conclusion:It was suggested that CdTe QDs at 0.5 nmol/ml could induce Oxidative damage effects in mice.
