Nicolau Syndrome after Intramuscular Injection: 3 Cases.
10.5999/aps.2012.39.3.249
- Author:
Seok Kwun KIM
1
;
Tae Heon KIM
;
Keun Cheol LEE
Author Information
1. Department of Plastic and Reconstructive Surgery, Dong-A University College of Medicine, Busan, Korea. sgkim1@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Necrosis;
Nicolau syndrome;
Injections;
Intramuscular
- MeSH:
Buttocks;
Debridement;
Dermatitis;
Diclofenac;
Erythema;
Humans;
Injections, Intramuscular;
Ketoprofen;
Muscles;
Necrosis;
Skin;
Sodium;
Subcutaneous Fat
- From:Archives of Plastic Surgery
2012;39(3):249-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the injection site, developing into erythema, a livedoid dermatitis patch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients were injected with drugs (diclofenac sodium, ketoprofen, meperidine) for pain relief. Three patients complained of pain, and a skin lesion was observed, after which necrosis developed on their buttocks. Each patient underwent debridement and coverage. The wound healed uneventfully. We report three cases of Nicolau syndrome in the buttocks following diclofenac intramuscular injection.
