Expression of hypoxia-inducible factor 1α, glucose transporter 1 and lactate dehydrogenase 5 in colorectal cancer and clinicopathologic significance
10.3760/cma.j.issn.0529-5807.2017.02.006
- VernacularTitle: 缺氧诱导因子1α、葡萄糖转运蛋白1和乳酸脱氢酶5在结直肠癌的表达及其意义
- Author:
Tongyin YANG
1
;
Langsong HAO
;
Dezheng GUO
Author Information
1. Department of Pathology, Guizhou Provincial People′s Hospital, Guiyang 550002, China
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Hypoxia-inducible factor 1, alpha subunit;
Glucose transporter type 1;
Lactate dehydrogenases
- From:
Chinese Journal of Pathology
2017;46(2):93-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and clinicopathological significance of hypoxia-inducible factor 1 alpha (HIF-1α), glucose transporter 1(GLUT-1) and lactate dehydrogenase(LDH)-5 in colorectal cancer.
Methods:The expression levels of HIF-1α, GLUT-1 and LDH-5 were detected by immunohistochemical staining in 142 specimens of human carcinoma in comparison with adjacent normal tissues.
Results:The expression levels of HIF-1α(78.2%, 111/142), GLUT-1(75.4%, 107/142) and LDH-5(68.3%, 97/142) were higher in tumor tissues than in adjacent normal tissues(14.8%, 21/142; 11.3%, 16/142; 7.0%, 10/142; P<0.01 for all three proteins), and such over-expression was significantly associated with lymphovascular invasion, tumor grade and pathological stages(all P<0.01). Additional studies showed that HIF-1α, GLUT-1 and LDH-5 were positively associated with each other(r<0.3, P<0.05 for all three proteins).
Conclusion:The data suggest that HIF-1α, GLUT-1 and LDH-5 expression may serve as prognostic indicators for colorectal cancer patients.
