Expression of PD-1/PD-L1 in triple-negative breast carcinoma and its significance
10.3760/cma.j.issn.0529-5807.2017.01.005
- VernacularTitle: PD-1/PD-L1在三阴性乳腺癌中的表达及其意义
- Author:
Wei ZHANG
1
;
Guoxiang XU
;
Jiajia LI
;
Xia LIU
;
Yujuan CHEN
;
Fan ZHANG
Author Information
1. Department of Pathology, Wannan Medical College Yijishan Hospital, Wuhu 241001, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Lymphocytes, tumor-infiltrating;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2017;46(1):20-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the expression of PD-1, PD-L1 and clinicopathologic parameters in triple negative breast carcinoma (TNBC).
Methods:Samples from 151 patients with TNBC and 65 cases of other breast carcinomas (non-TNBC) were examined for PD-L1 and PD-1 expression by immunohistochemical staining on tissue microarray.
Results:The expression of PD-L1 and PD-1 in the tumor cells and interstitial lymphocytes in TNBC was significantly (P<0.05)higher than that in non-TNBC.In TNBC, the expression rates of PD-L1 in the cancer nests and stroma were 16.6%(25/151) and 25.2%(38/151)respectively.The former was positively correlated with tumor histological grade and lymph node metastasis (P<0.05), and the latter only with tumor histological grade (P<0.05). The expression rate of PD-1 was 27.2% (41/151), and correlated with PD-L1 expression in stromal tumor-infiltrating lymphocytes (P<0.05).
Conclusion:The expression of PD-L1 in TNBC is significantly correlated with high-grade histology, lymph node metastasis and PD-L1 expression in stromal tumor-infiltrating lymphocytes.
