Influence of n-hexane on vascular endothelial active substances in brain tissue in mice
10.3760/cma.j.issn.1001-9391.2017.01.012
- VernacularTitle: 正己烷对小鼠脑组织血管内皮物质的影响
- Author:
Li LIN
1
;
Zhaoqiang ZHANG
;
Chunzhi ZHANG
Author Information
1. Key Laboratory of Occupational Health & Environmental Medicine, School of Public Health, Jining Medical University, Jining 272067, China
- Publication Type:Case Reports
- Keywords:
n-hexane;
AngiotenisnⅡ;
Mice
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(1):49-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of n-hexane on vascular endothelial active substances in brain tissue in mice and its significance.
Methods:A total of 48 healthy Kunming mice were randomly divided into high-dose exposure group, middle-dose exposure group, low-dose exposure group, and control group, with 12 mice in each group. All groups except the control group were exposed to n-hexane via static inhalation (0.035 g/L, 0.018 g/L, and 0.009 g/L for the high-, middle-, and low-dose exposure groups, respectively) 4 hours a day for 21 days. the mice in the control groups were not exposed to n-hexane. After the exposure, the lev-els of endothelin-1 (ET-1) , nitric oxide (NO) , and angiotensin II (Ang II) in brain tissue were measured in all groups.
Results:There were significant differences in the levels of ET-1, NO, and Ang II between the three ex-posure groups and the control group (P<0.05). Compared with the control group, the high-and middle-dose expo-sure group had significant increases in the levels of ET-1 and Ang II and the high-dose exposure group had a sig-nificant reduction in the level of NO (P<0.05 or P<0.01).
Conclusion:n-Hexane can affect the vascular endothe-lial active substances in brain tissue in mice, and the changes and imbalance in vascular endothelial active sub-stances may be one of the reasons for central nervous system impairment caused by n-hexane.
