Postoperative survival analysis of patients with stage Ⅲ-pN2 non-small cell lung cancer
10.3760/cma.j.issn.0253-3766.2018.10.011
- VernacularTitle: pN2 Ⅲ期非小细胞肺癌患者术后生存的影响因素
- Author:
Xiaowei WU
1
;
Tao CHEN
2
;
Sui YIN
3
;
Yu DENG
1
;
Bo ZHAO
1
Author Information
1. Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Thoracic Surgery, The First People′s Hospital of Yueyang, Yueyang 414000, China
3. Department of Thoracic Surgery, Jiangxi Provincial People′s Hospital, Nanchang 330006, China
- Publication Type:Clinical Trail
- Keywords:
Carcinoma, non-small-cell lung;
Staging;
Mediastinal lymph nodes;
Prognosis
- From:
Chinese Journal of Oncology
2018;40(10):782-786
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of mediastinal lymph node resection, metastasis status and treatment on the prognosis of patients with stage Ⅲ-pN2 non-small cell lung cancer (NSCLC).
Methods:Clinical data of 206 patients who were pathologically diagnosed as stage Ⅲ-pN2 NSCLC in Tongji Hospital from July 2006 to Dec 2009 were retrospectively analyzed and followed up. Log rank test and Cox proportional hazards regression model were used to analyze the prognostic significance of mediastinal lymph node excision, metastasis state and treatment.
Results:The median overall survival (OS) time of the whole group was 29.6 months, and the median disease-free survival (DFS) time was 27.2 months. Univariate analysis showed that the less number of mediastinal lymph node stations with metastasis (single station), the less number of mediastinal lymph nodes involved (less than 2), and postoperative chemotherapy were associated with longer postoperative OS and DFS time (P<0.05 for all). The patients with skip metastasis, negative metastasis of subcarinal lymph node, the lower mediastinal lymph node metastasis rate (MLNR<33%) and postoperative radiotherapy had longer OS and DFS time than those without these factors (P<0.05 for all). Multivariate analysis showed that metastasis of subcarinal lymph node, MLNR and postoperative chemotherapy were the independent prognostic factors for patients with stage Ⅲ-pN2 NSCLC (P<0.05 for all).
Conclusion:Metastasis of subcarinal lymph nodes and the higher MLNR might shorten the postoperative survival time of NSCLC patients with stage Ⅲ-pN2, whereas postoperative chemotherapy prolongs the survival time.
