Regulation of Wnt/β-catenin signaling in bone development and bone tumor
10.3760/cma.j.issn.0529-5815.2018.10.020
- VernacularTitle: Wnt/β－catenin信号转导通路对骨形成和骨肿瘤的调控作用
- Author:
Zhenhua ZHOU
1
;
Jianru XIAO
Author Information
1. Department of Orthopaedic Oncology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China
- Publication Type:Review
- Keywords:
Wnt proteins;
Bone neoplasms;
Microenvironment;
Wnt/β
-catenin signaling pathway
- From:
Chinese Journal of Surgery
2018;56(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
The Wnt/β-catenin signaling pathway is crucial in bone development and homeostasis.Normally, it has been suggested to play a significant role in regulation of osteogenic differentiation of bone marrow mesenchymal stem cells, osteoclastogenesis and?偅ibone mineral density. Dysregulated Wnt/β-catenin signaling pathway is responsible for bone tumor, metabolic bone disease, degenerative bone disease and it related to development and invasion of osteosarcoma and Ewing′s sarcoma.Studies of the molecular mechanisms of Wnt/β-catenin signaling pathway provide theoretical basis of a potential target for bone diseases.
