Mechanism of herpes virus latent infection and its significance
10.3760/cma.j.issn.1009-9921.2018.05.001
- VernacularTitle: 疱疹病毒隐性感染的机制及意义
- Author:
Kefu WU
1
;
Xiaotong MA
;
Guoguang ZHENG
;
Yuhua SONG
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
- Publication Type:Review
- Keywords:
Simplexvirus;
Latent infection;
Herpesvirus 4, human
- From:
Journal of Leukemia & Lymphoma
2018;27(5):257-262
- CountryChina
- Language:Chinese
-
Abstract:
Human herpes virus (HHV) spreads widely in a latent-infected way. HHV is divided into 3 kinds and 8 types. Herpes simplex caused by HHV-1 and HHV-2, varicella-zoster caused by HHV-3 and Epstein-Barr virus (EBV) known as HHV-4 and recognized firstly as human tumor virus, are well known in the field of virology. With the application of hematopoietic stem cell transplantation , cytomegalovirus (HHV-5) and HHV-6 have gained an increasing attention. The biological characteristic of HHV is latent infection in a long time and HHV can be reactivated in some immunocompromised individuals. Clarification of latent infection mechanism will help provide targets for therapy and lay a foundation for clinical treatment. This paper summarizes the clinical significance of HHV infection. Taking the mechanism of EBV latent infection as an example, the pathway and significance as well as strategy of co-evolution of organism and virus will be discussed in order to provide clues for prevention and therapy.
