Transformation of endogenous reactive oxygen species participates into bacterial antibiotic resistance
10.3760/cma.j.issn.0253.9624.2018.04.022
- VernacularTitle: 细菌耐药机制：内源活性氧分子的角色
- Author:
Xin LI
1
;
Yongliang ZHONG
;
Youjun FENG
Author Information
1. College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China
- Publication Type:Review
- Keywords:
Antibiotic resistance;
Reactive oxygen species;
Hydrogen peroxide;
Mesosome-like structures;
Drug resistance
- From:
Chinese Journal of Preventive Medicine
2018;52(4):446-450
- CountryChina
- Language:Chinese
-
Abstract:
A growing body of diversified antibiotic resistances raises a significant challenge to anti-infection clinical therapeutics. The emergence of superbugs carrying MCR-1/2 or NDM-1 determinants underlines the importance and urgency in elucidation of molecular mechanisms shared by antibiotic resistances. It is aware that different classes of bactericidal antibiotics consistently stimulate the production of deleterious reactive oxygen species (ROS), which are accompanied with metabolic disturbance. The different destinations of ROS determine its consequence on bacterial fate. Here, we review antibiotic-induced production, progression and transformation of ROS, as well as its role in the development of antibiotic resistance. Additionally, we anticipate that mesosome-like structures-aided exclusion of hydrogen peroxide might represent a previously-unknown mechanism for antibiotic resistance. This mini-review is aiming to present an update overview on antibiotic resistance and provide clues to the development of novel antibiotics.
