A multicenter, large-sample, randomized clinical trial on improving the median survival time of advanced non-small cell lung cancer by combination of Ginseng Rg3 and chemotherapy
10.3760/cma.j.issn.0253-3766.2018.04.011
- VernacularTitle: 参一胶囊联合化疗改善晚期非小细胞肺癌患者预后的多中心大样本随机临床研究
- Author:
Ying ZHANG
1
;
Xueqian WANG
1
;
Hao LIU
1
;
Jie LIU
1
;
Wei HOU
1
;
Hongsheng LIN
1
Author Information
1. Department of Oncology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
- Publication Type:Clinical Trail
- Keywords:
Carcinoma, non-small-cell lung;
Combined treatment of traditional Chinese medicine and western medicine;
Prognosis;
Randomized double blind trial
- From:
Chinese Journal of Oncology
2018;40(4):295-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of the combination of chemotherapy and Ginseng Rg3 on advanced non-small cell lung cancer(NSCLC).
Methods:In the multi-center, large-sample, randomized, double blind trial, 414 patients with Ⅲ-Ⅳ NSCLC were enrolled.199 were in the experimental group and 215 the control group. The patients in the experimental group were treated with the standard first-line chemotherapy combined with Ginseng Rg3. The patients in the control group were treated with the same chemotherapy combined with placebo. Median overall survival (OS), Karnofsky performance scale (KPS), Traditional Chinese Medicine (TCM) symptoms score and side effects of two groups were observed as main indexes.
Results:The median OS were 12.03 months in the experimental group, which was significantly better than that in the control group (8.46 months, P<0.05). Hemoglobin and white blood cells were decreased after the first and second cycle of treatment in both groups. Both adverse events were significantly milder in the treatment group (P<0.05). In addition, after two courses of treatment, the KPS of patients was 78.95±9.14 in the experimental group and 76.77±9.15 in the control group, while the TCM symptoms score was 2.45±1.73 in the experimental group and 2.92±2.06 in the control group, with significant difference (P<0.05).
Conclusions:Combination of TCM with Western medicine such as chemotherapy could prolong the survival of patients with advanced NSCLC. The combined therapy improved patients′ symptoms and reduced chemotherapy induced myelosuppression.
