Determination of Sevoflurane, Isoflurane and Enflurane in the air of workplace by gas chromatography
10.3760/cma.j.issn.1001-9391.2019.06.012
- VernacularTitle: 工作场所空气中七氟烷、异氟烷、恩氟烷气相色谱测定方法
- Author:
Tiandi LI
1
;
Wen ZHANG
;
Jinmin CAI
;
Yiran LIN
;
Jianpei YUN
;
Fen LIU
Author Information
1. Prevention and Treatment Center for Occupational Diseases, Shenzhen 518001, China
- Publication Type:Journal Article
- Keywords:
Workplace;
Air;
Sevoflurane;
Isoflurane;
Enflurane;
Gas chromatograph
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(6):453-456
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a solvent desorption gas chromatographic method for determination of Sevoflurane, Isoflurane and Enflurane in the air of the Workplace.
Methods:Sevoflurane, Isoflurane and Enflurane were collected with activated carbon tube and desorbed with dichloromethane, separated with DB-1 capillary columns, and then detected with flame ionization detector.
Results:The linearity ranges were 1.9-304.8 μg/ml for Sevoflurane, 2.1-300.4 μg/ml for Isoflurane and 1.7-305.2 μg/ml for Enflurane, The correlation coefficient was both >0.999. Their limits of detection were 0.6 μg/ml, 0.6 μg/ml and 0.5 μg/ml, and Their limits of quatification were 1.9 μg/ml, 2.1 μg/ml and 1.7 μg/ml, and their minimum detectable concentrations were 0.1、0.2 and 0.1 mg/m3 per 4.5 L of air. Their relative standard deviations (RSD) were 2.5%-3.0%, 2.3%-3.1% and 2.2%-3.0%. The average desorption efficiencies were 101.1%-103.3%, 100.7%-102.7% and 101.0%-102.9%. The sampling efficiency was both 100%. The breakthrough volume of 100 mg actived carbon was 3.7 mg, 3.4 mg and 3.4 mg. Sevoflurane, Isoflurane and Enflurane in activated carbon tube could be kept at least 10 days at room temperature without significant losses.
Conclusion:The method shows lower detection limit, high accuracy and precision. It is feasible for determination of Sevoflurane, Isoflurane and Enflurane in the air of workplace.
