Analysis on the heritability of diabetes, based on data from the Chinese adult twins

Fengxia GAN; Wenjing GAO; Jun LYU; Canqing YU; Shengfeng WANG; Zengchang PANG; Liming CONG; Zhong DONG; Fan WU; Hua WANG; Xianping WU; Guohong JIANG; Xiaojie WANG; Binyou WANG; Zheng CHANG; Ralf KUJA-HALKOLA; Weihua CAO; Liming LI

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Analysis on the heritability of diabetes, based on data from the Chinese adult twins

VernacularTitle: 中国成年双生子人群的糖尿病遗传度研究
Author: Fengxia GAN ¹ ; Wenjing GAO ¹ ; Jun LYU ¹ ; Canqing YU ¹ ; Shengfeng WANG ¹ ; Zengchang PANG ² ; Liming CONG ³ ; Zhong DONG ⁴ ; Fan WU ⁵ ; Hua WANG ⁶ ; Xianping WU ⁷ ; Guohong JIANG ⁸ ; Xiaojie WANG ⁹ ; Binyou WANG ¹⁰ ; Zheng CHANG ¹¹ ; Ralf KUJA-HALKOLA ¹¹ ; Weihua CAO ¹ ; Liming LI ¹
Author Information

1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
2. Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
3. Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China
4. Beijing Center for Disease Control and Prevention, Beijing 100013, China
5. Shanghai Center for Disease Control and Prevention, Shanghai 200336, China
6. Jiangsu Center for Disease Control and Prevention, Nanjing 210008, China
7. Sichuan Center for Disease Control and Prevention, Chengdu 610041, China
8. Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
9. Qinghai Center for Disease Control and Prevention, Xining 810007, China
10. Harbin Medical University, Harbin 150001, China
11. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
Publication Type:Journal Article
Keywords: Diabetes mellitus; Twin study; Heritability
From: Chinese Journal of Epidemiology 2019;40(4):389-393
CountryChina
Language:Chinese
Abstract: Objective:To analyze the heritability of diabetes among the Chinese twin adults.
Methods:A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model.
Results:After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively.
Conclusions:Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.