Bronchial hyperrseponsiveness to methacholine in allergic rhinitics sensitized to house dust mites.
- Author:
Woo Kyung KIM
;
Jun Woo BAHN
;
Byung Jae LEE
;
Yoon Keun KIM
;
Sang Heon CHO
;
Kyung Up MIN
;
You Young KIM
- Publication Type:Original Article
- Keywords:
bronchial responsiveness allergic rhinitis house dust mites methacholine
- MeSH:
Adrenal Cortex Hormones;
Adult;
Allergens;
Asthma;
Bronchial Provocation Tests;
Dust*;
Humans;
Methacholine Chloride*;
Pyroglyphidae*;
Rhinitis;
Skin;
Surveys and Questionnaires
- From:Journal of Asthma, Allergy and Clinical Immunology
1998;18(2):308-315
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Allergic rhinitis is often associated with bronchial asthma, and intranasal treatment with topical corticosteroids reduces bronchial responsiveness. OBJECTIVE: In this study, it was evaluated that the bronchial responsiveness to methacholine increased in non-asthmatic adults with house dust mites (HDM)-sensitive allergic rhinitis compared to those without, chronic nasal symptoms. SUBJECTS AND METHODS: A questionnaire, skin prick t,est to common inhalant allergens, and methacholine bronchial provocation test (MBPT) were performed in a total of 216 subjects, who were composed of 40 non-asthmatic subjects with HDM-sensitive allergic rhinitis (HAR), 63 HDM-sensitive subjects without nasal symptoms (HS), and 113 non-atopic subjects without nasal symptoms (NHS). The bronchial responsiveness was evaluated by positive rate of MBPT (PC,-methacholine200mg/ml), provocative concentration of methacholine at which FEV, decline to 15% compared to baseline value (PC,-methacholine), and slope of dose-response curve (%fall of FEV, / log[last concentrat,ion of methacholine, mg/ml]). RESULTS: Positive rate of MBPT was significantly increased in HAR than in HS and NHS, and there was no difference between HS and NHS (77.9% vs. 50.7% vs. 38.0%). Log PC[5- methacholine was lower in HAR than in HS and NHS, and lower in HS than in NHS (mean+ SE, 1.568+0.126 vs. 2.05+0.085 vs. 2.277+0.047). Slope of dose-response curve was higher in HAR than in HS and NHS, and there was no difference bet,ween HS and NHS (mean+SE, 22.7 + 11.3 vs. 7.3+ 1.2 vs. 4.9+ 0.5%/mg/ml); CONCLUSION: In non-asthmatic adults with HDM-sensitive allergic rhinitis, the bronchial responsiveness to methacholine increased compared to those without chronic rhinitis.
