Submucosal tunneling endoscopic resection for submucosal tumors originating from muscularis propria layer at esophagogastric junction
10.3760/cma.j.issn.0253-3766.2019.02.010
- VernacularTitle: 内镜经黏膜下隧道肿瘤切除术治疗食管胃结合部固有肌层来源的黏膜下肿瘤
- Author:
Xiaojuan ZHENG
1
;
Yong LIU
;
Jiqing ZHU
;
Lizhou DOU
;
Yueming ZHANG
;
Shun HE
;
Yan KE
;
Xudong LIU
;
Yumeng LIU
;
Guiqi WANG
Author Information
1. Department of endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Clinical Trail
- Keywords:
Esophagogastric junction;
Submucosal tumors;
Muscularis propria layer;
Submucosal tunneling endoscopic resection
- From:
Chinese Journal of Oncology
2019;41(2):129-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the short-term outcomes and safety of submucosal tunneling endoscopic resection (STER) for submucosal tumors (SMT) originating from muscularis propria (MP) layer at esophagogastric junction.
Methods:The clinical data of 31 patients with SMT originating from MP layer at esophagogastric junction underwent STER were collected and retrospectively analyzed.
Results:The success rate of STER of the thirty-one patients was 100%. The mean tumor size was (2.5±1.3) cm and the average operative time was (95.9±56.7) min. Perforation occurred in 3 patients and was successfully clipped by endo-clips during operation. One patient developed delayed bleeding and the bleeding was stopped by endoscopic hemostasis. Twenty-nine leiomyomas and two stromal tumors (GIST) were finally pathologically diagnosed. No local recurrence and distant metastasis were noted during the mean 15.4 months follow-up of 20 cases. According to the lesion size, 31 patients who received STER were divided into two groups. The operation time of maximum diameter ≥3.5 cm group was (134.0±70.6) min, significantly longer than (80.3±42.6) min of maximum diameter <3.5 cm group (P=0.014). However, the en bloc removal rate, postoperative hospital stay and the complication incidence between the two groups had no obvious differences (P>0.05). Univariate analysis showed that the piecemeal removal group had longer tumor diameter, higher incidence of irregular tumor morphology, and longer operative time than the en bloc removal group (all P<0.05). Stepwise logistic regression analysis showed that irregular shape was a risk factor for failure of en bloc removal (OR=18.000, 95% CI: 1.885~171.88, P=0.012).
Conclusion:As a new method of minimally invasive treatment, STER technology appears to be a safe and effective option for patients with SMT originating from MP layer at esophagogastric junction.
