Mechanobiological Response and Network Formation in Central Nervous Development
10.16156/j.1004-7220.2018.05.15
- VernacularTitle:中枢神经发育中的力学-生物学响应与网络形成
- Author:
Fei ZHAO
1
;
Xuyi CHEN
2
;
Xizheng ZHANG
3
Author Information
1. Graduate School, Jinzhou Medical University;Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Center for Neurology and Neurosurgery, Affiliated Hospital of the Logistics University of the Chinese People’s Armed Police Force
2. Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury and Neuroscience, Center for Neurology and Neurosurgery, Affiliated Hospital of the Logistics University of the Chinese People’s Armed Police Force
3. Institute of Medical Equipment, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
nerve cell;
central nervous system (CNS);
cell-cell interaction;
mechanobiological response;
biomechanics
- From:
Journal of Medical Biomechanics
2018;33(5):E471-E476
- CountryChina
- Language:Chinese
-
Abstract:
In the process of central nervous system (CNS) development and maturation, the biomechanical factors have not been highly valued for a long time. In recent years, a large number of studies have shown that mechanical environment strongly affects the migration, differentiation and maturation of nerve cells, as well as the cell-cell interactions. Mechanical factors play an important role in realization of the structure and function of the brain and spinal cord. This review briefly summarized the role of biomechanics in CNS perception, path-finding, regulation and network shaping during CNS development. The effects of static and dynamic mechanics on mechanobiological response of nerve cells were also introduced, hoping to provide some ideas for CNS reconstruction and repair in future.
