Longitudinal study on quality of life and its influencing factors in children with acute lymphoblastic leukemia during chemotherapy
10.3760/cma.j.issn.1672-7088.2019.34.008
- VernacularTitle: 急性淋巴细胞白血病患儿化疗期间生命质量及其影响因素的纵向研究
- Author:
Rongrong LI
1
;
Yuying CHAN
2
;
Jinling MA
1
;
Qi YANG
1
;
Pengfei ZHENG
3
Author Information
1. Department of Hematologists, Children′s Hospital Affiliated to Soochow University, Suzhou 215025, China
2. Discipline Supervision Office, Children′s Hospital Affiliated to Soochow University, Suzhou 215025, China
3. School of Nursing, Medical College of Soochow University, Suzhou 215006, China
- Publication Type:Clinical Trail
- Keywords:
Leukemia;
Children;
Chemotherapy;
Quality of life;
Longitudinal study
- From:
Chinese Journal of Practical Nursing
2019;35(34):2676-2681
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dynamic changes of quality of life and its influencing factors in children with acute lymphoblastic leukemia during chemotherapy.
Methods:A total of 134 children who were diagnosed with acute lymphoblastic leukemia were selected. The demographic questionnaire and Pediatric Quality of Life InventoryTM General Core Module were completed in children at three different time points during chemotherapy (the first month, the third month, and the sixth month of chemotherapy).
Results:There were significant differences in the quality of life between children with acute lymphoblastic leukemia (t=-23.117-209.225, P<0.01). Multiple factors analysis showed that the factors influencing the quality of life of children at the first month of chemotherapy were age (t=-10.413, P=0.000) , and family emotional support (t=2.231, P=0.027) ; the factors at the third month of chemotherapy included age (t=-12.439, P=0.000) , whether the child was the only child (t=2.267, P=0.025) , education level of primary caregiver (t=2.091, P=0.038) , and family emotional support (t=5.374, P=0.014) ; the factor at the sixth month of chemotherapy were age (t=-11.254, P=0.000) , and family emotional support (t=2.184, P=0.035) .
Conclusions:The total quality of life and the scores of all dimensions of children with acute lymphoblastic leukemia were lower and showed dynamic changes. Age and family emotional support were continuing factors influencing quality of life. Medical staff should take targeted interventions according to the characteristics of the quality of life of children at different ages, and guide and help parents and children to establish good family emotional support and improve their quality of life.
