Study on the correlation between serum trace elements, homocysteine and cognitive function in patients with Alzheimer's disease
10.3760/cma.j.issn.1008-6706.2019.18.008
- VernacularTitle: 阿尔茨海默病患者血清微量元素同型半胱氨酸水平与认知功能的相关性研究
- Author:
Liming CHEN
1
;
Long HU
2
Author Information
1. Department of Internal Medicine, the Seventh People's Hospital of Wenzhou, Wenzhou, Zhejiang 325000, China
2. Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
- Publication Type:Journal Article
- Keywords:
Alzheimer'
s disease;
Homocysteine;
Iron;
Copper;
Zinc;
Cognitive
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(18):2209-2214
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the correlation between serum trace elements and homocysteine (Hcy) levels and cognitive function in elderly patients with Alzheimer's disease(AD).
Methods:From January 2017 to December 2018, 65 patients with AD who were diagnosed and treated in the Department of Internal Medicine of the Seventh People's Hospital of Wenzhou were selected in this study.In the same period, 50 healthy people in the physical examination center of our hospital were selected as the control group.MMSE scale was used to evaluate the cognitive status of patients.The score of MMSE 27-30 belongs to normal cognitive function.The score of MMSE<27points is cognitive dysfunction.The score of MMSE 21-26points is mild cognitive dysfunction.The score of MMSE 10-20points is moderate cognitive dysfunction.The score of MMSE 0-9points is severe cognitive dysfunction.The levels of Hcy, serum copper, serum iron and serum zinc in all subjects were detected and analyzed.The normal value of copper is 7.12-33.8 μmol/L.The normal value of zinc is 67.72-111.30 μmol/L.The normal value of iron is 7.27-9.85 μmol/L.
Results:The serum copper level of the control group was significantly lower than that of the moderate and severe patients, which of the mild patients was significantly lower than that of the moderate and severe patients(F=12.796, P=0.003). The level of serum iron in the control group was significantly higher than that in the mild group, and there was statistically significant difference between the moderate group and severe group (F=3.332, P=0.021). The serum zinc level in the control group was significantly higher than that in the mild, moderate and severe patients (F=123.618, P=0.000). There were statistically significant differences in serum zinc concentration between mild and moderate patients and severe patients (F=26.3672, P=0.0000). The serum zinc concentration in moderate patients was significantly lower than that in severe patients (F=12.375, P=0.009). The levels of Hcy in mild, moderate and severe patients in the study group were significantly higher than those in the control group, and the difference was statistically significant(F=6.549, P=0.020). Serum copper concentration was positively correlated with MMSE score (r=10.100, P=0.000). The higher the serum copper concentration, the higher the MMSE score, the more serious the cognitive impairment.The serum zinc and iron levels in patients were negatively correlated with the MMSE score (r=6.039, P=0.037). The lower the serum zinc concentration, the higher the scores of MMSE scale and the lighter the degree of cognitive impairment.
Conclusion:The changes of serum iron, zinc and copper levels in patients with AD are closely related to cognitive function.Serum copper is positively correlated with the severity of the disease, while serum zinc is negatively correlated with iron and severity of the disease.
