Analysis of Molecular Mechanism of Huangliantang in Treatment of Gastritis Based on Integrated Pharmacology Platform of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20182308
- VernacularTitle: 基于中药整合药理学平台分析黄连汤治疗胃炎的作用机制
- Author:
Zhi-chun WU
1
;
Hua-yun YU
1
;
Cheng-bo ZHANG
1
;
Ting MA
1
;
Xin ZONG
1
;
Xu-ming JI
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China
- Publication Type:Research Article
- Keywords:
Huangliantang;
integrated pharmacology;
gastritis;
mechanism of action;
targets;
pathway analysis;
interaction network
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(4):57-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effective substance basis and possible mechanism of Huangliantang in treatment of gastritis. Method: Integrated pharmacology platform of traditional Chinese medicine was employed to predict the main active ingredients and functional targets of Huangliantang in treatment of gastritis, network of composition target-disease target of Huangliantang was constructed, key nodes were screened for enrichment analysis of pathways, and the possible mechanism of Huangliantang in treatment of gastritis with multiple ingredients-multiple targets-multiple pathways was explored. Result: A total of 175 predicted active ingredients of Huangliantang interacted with 538 key targets about gastritis, the regulation and treatment of gastritis during its different pathological stages, such as Helicobacter pylori infection, gastric mucosal damage and gastric mucosal atrophy, were involved through chemokine, T cell receptor, estrogen and other signaling pathways. Conclusion: This research may reveal the potential active ingredients of Huangliantang in treatment of gastritis and its possible mechanism, and it also provides a theoretical basis for further experimental research of pharmacodynamic substance basis and mechanism of action.
