LINC Complex and Intracellular Mechanotransduction
10.16156/j.1004-7220.2019.03.17
- VernacularTitle:LINC复合体与细胞内机械力传导
- Author:
Guoying ZHENG
1
;
Xudong WU
2
;
Lei SUI
1
Author Information
1. Hospital of Stomatology, Tianjin Medical University
2. Tianjin Key Laboratory of Medical Epigenetics, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Cell Biology, Tianjin Medical University
- Publication Type:Journal Article
- Keywords:
mechanotransduction;
LINC complex;
cytoskeleton
- From:
Journal of Medical Biomechanics
2019;34(3):E327-E332
- CountryChina
- Language:Chinese
-
Abstract:
As mechanoreceptors, cells can sense and transmit mechanical forces exerted on their surfaces, meanwhile adjust their own mechanical properties to maintain stability. The mechanical force is transferred from cell surface or cytoplasm to the nucleus depending on the complete cytoskeletal system. This cytoskeletal system consists of cytoplasmic skeleton and nuclear skeleton, and these two parts are connected mechanically by the LINC complex (linker of nucleoskeleton and cytoskeleton complex), which plays an important role in cellular mechanotransduction. This review discusses the basic structure of mechanical transmission part in LINC complex and the changes in the nuclear morphology, the location of transcription factor, and the spatial conformation of chromatin induced by mechanotransduction, so as to lay a foundation for further exploring the role of LINC complex in cell mechanotransduction and gene expression.
