Effect of Modified Shenling Baizhu San on Inflammatory Factors and Peripheral Blood T Lymphocyte Subsets in Spleen Deficiency Wetness Type Subacute Eczema
10.13422/j.cnki.syfjx.20190330
- VernacularTitle: 参苓白术散加减治疗脾虚湿蕴型亚急性湿疹临床疗效及对炎症因子和外周血T淋巴细胞亚群的影响
- Author:
Zhi-ren YU
1
;
Jing SHI
1
;
Cai-xia WANG
1
;
Xin GUO
1
;
Yong-ge GU
1
;
Yu ZHANG
1
Author Information
1. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
- Publication Type:Research Article
- Keywords:
Shenling Baizhu San;
eczema;
spleen deficiency wetness type;
inflammatory factors;
T lymphocyte subsets
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(5):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficacy modified Shenling Baizhu San in treating patients with spleen deficiency wetness type subacute eczema, and its effect on the inflammatory factors and peripheral blood T lymphocyte subsets, so as to provide a theoretical basis for clinical treatment. Method: Totally 176 cases of spleen deficiency wetness type subacute eczema treated at our hospital from Jan. 2016 to Dec. 2017 were selected and randomly divided into control group (88 cases) and observation group (88 cases). Control group was treated with levocetirizine hydrochloride tablets and compound econazole nitrate gel, and observation group was given modified Shenling Baizhu San in addition to therapy of control group for 4 weeks. The clinical efficacy, pruritus score, severity index(EASI)score, dermatology quality of life scales(DQOLS) score and recurrence rate were observed,and inflammatory factor and peripheral blood T lymphocyte subgroup level were detected. Result: After treatment, the pruritus score and EASI score in observation group were lower than those before treatment (P<0.05), and those of observation group were significantly lower than those of control group (P<0.05). However, the DQOLS score was higher than that before treatment, and significantly higher than that of control group (P<0.05). The clinical effective rate of observation group was significantly higher than that of control group (P<0.05). After treatment, the levels of interleukins(IL)-1β, IL-2, IL-4, IL-5 and tumor necrosis factor(TNF) -α in observation group were lower than those before treatment (P<0.05), and the levels of CD4+ and CD4+/CD8+ were higher than those of before treatment, and significantly higher than those of control group (P<0.05). During the 6-month follow-up, the recurrence rate of observation group was significantly lower than that of control group (P<0.05). Conclusion: Modified Shenling Baizhu San could enhance the clinical efficacy by inhibiting the inflammatory reaction and regulating the immune function of patients.
