Clinical Observation of Addition and Subtraction Therapy and External Washing Treatment of Danggui Niantongtang to Knee Osteoarthritis with Heumatism Heat Bi Syndrome
10.13422/j.cnki.syfjx.20191331
- VernacularTitle: 当归拈痛汤加减内服外洗治疗膝骨性关节炎风湿热痹证的临床观察
- Author:
Hai-ling ZHAO
1
;
Zong-bo ZHOU
1
;
Jian-qiang LI
1
;
Jian HUANG
1
;
Yi CHENG
1
;
Zhi-fu LU
1
Author Information
1. Haikou Traditional Chinese Medicine Hospital, Haikou 570216, China
- Publication Type:Research Article
- Keywords:
knee osteoarthritis;
heumatism heat Bi syndrome;
Danggui Niantongtang;
internal service;
outside washing;
disease activity
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(13):105-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the short-term clinical efficacy of addition and subtraction therapy and external washing treatment of Danggui Niantongtang to knee osteoarthritis (KOA) with heumatism heat Bi syndrome and to investigate its effect on disease activity. Method:One hundred and eighteen patients with KOA were randomly divided into control group (58 cases) and observation group (60 cases) by random number table. Patients in control group got celecoxib capsules, 0.2 g/time, 1 time/day, diclofenac diethylamine emulgel for the pain, 3 times/days. Patients in observation group got addition and subtraction therapy and external washing treatment of Danggui Niantongtang. The course of treatment was 2 weeks in both groups. Before treatment and at the 2th, 4th, 6th and 14th weeks after treatment, scores of visual analog scale (VAS) were graded for pain in walking and tranquillization. Function of knee joint was evaluated by western Ontario and McMaster university osteoarthritis index (WOMAC) both before and after treatment. Scores of heumatism heat Bi syndrome and Japanese Orthopaedic Associate (JOA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), superoxide dismutase (SOD), interleukin-1β (IL-1β), interleukin-6, tumor necrosis factor-α (TNF-α) and matrix metalloproteinases-3 (MMP-3) levels were evaluated. Result:At the 6th and 14th weeks after treatment, scores of VAS in observation group were lower than those in control group during walking and tranquillization time. Scores of three dimensions in WOMAC (pain, stiffness, joint function) and the total score of WOMAC in observation group were all lower than those in control group (P<0.01). The score of main symptoms of heumatism heat Bi syndrome and the total score in observation group were lower than those in control group (P<0.01). After treatment, levels of ESR, CRP, IL-1β, IL-6, TNF-α and MMP-3 were lower than those in control group, and level of SOD was higher than that in control group (P<0.01). Conclusion:Addition and subtraction therapy and external washing treatment of Danggui Niantongtang can relieve the pain and degree of disease caused by KOA with heumatism heat Bi syndrome, swelling and dysfunction, and can control acute inflammation index, reduce disease activity.
