Clinical Effect of Acupoint Application Therapy of Modified Wuzhuyu Binglang Tang on Chronic Non-atrophic Gastritis
10.13422/j.cnki.syfjx.20190729
- VernacularTitle: 吴茱萸槟榔汤加减穴位贴敷治疗慢性非萎缩性胃炎的临床观察
- Author:
Xiao-lei JING
1
;
Yong-qin ZHANG
1
;
Ya-jiao GU
2
;
Jing-lan FEI
2
Author Information
1. Nursing Schools Henan, University of Chinese Medicine, Zhengzhou 450000, China
2. The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450003, China
- Publication Type:Research Article
- Keywords:
chronic non-atrophic gastritis;
Wuzhuyu Binglang Tang;
external treatment;
gastrointestinal function;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(12):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of acupoint application therapy of modified Wuzhuyu Binglang Tang on chronic non-atrophic gastritis (CNAG) and the mechanism of action. Method: Two hundred and seventeen patients were randomly divided into control group (107 cases) and observation group (110 cases) by random number table. Both groups' patients got Omeprazole enteric-coated tablets half an hour before meals, 20 mg/time, 2 times/day, bismuth potassium citrate tablets half an hour before meals, 2 tablets/time, 2 times/day, amoxicillin capsules after meals, 1.0 g/time, 2 times/day, two dimensional furazolidone tablets after meals, 1 tablet/time, 2 times/day, mosapride citrate tablets, 5 mg/time, 3 times/day. The treatment lasted for 2 weeks. Patients in observation group got acupoint application of modified Wuzhuyu Binglang Tang at Zhongwan, Weiyu, Geyu, Shenyu and Piyu for 6 h/day, 1 time/day. And the patients in control group got model drug at the same acupoints. Before and after treatment, epigastric fullness and epigastric pain were scored. Levels of motilin, gastrin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) were detected. In 1-month follow-up visit, Hp and adverse reaction were detected under gastroscope. Result: The clinical effect in observation group under gastroscope was better than that in control group (Z=2.015, P<0.05), and the scores of traditional Chinese medicine symptoms in observation group was better than those in control group (Z=2.663, P<0.01). And scores of epigastric fullness, epigastric pain, post-food abdominal distention, early satiety, nausea, hiccup, pantothenic acid, heating, nausea and vomiting were lower than those in control group (P<0.01). The negative conversion rate of Hp in observation group was 93.64%, which was higher than 84.11%in control group (χ2=5.002, P<0.05). And levels of TNF-α and IL-6 were lower than those in control group, PGE2 was higher than that in control group (P<0.01). And mild erythema and itching disappeared after symptomatic treatment. Conclusion: The acupoint application therapy of modified Wuzhuyu Binglang Tang can relieve the clinical symptoms, promote the negative conversion rate of Hp, improve the clinical effect, regulate gastrointestinal hormones, inhibiting release of inflammatory factors, protect gastric mucosa, and improve gastrointestinal function, with safety in clinic use.
