Effect of Liuwei Dihuangwan on Blood Metabolism During Growth and Development of Rats
10.13422/j.cnki.syfjx.20190848
- VernacularTitle: 六味地黄丸对大鼠生长发育过程中血液代谢的影响
- Author:
Shu-yu KANG
1
;
Ai-jia ZHANG
1
;
Jia-qi ZHANG
1
;
Ping WANG
1
;
Xi-jun WANG
1
Author Information
1. Sino-America Chinmedomics Technology Collaboration Center, Key Laboratory of Serum Pharmacochemistry, Research Center of Chinmedomics, State Administration of Traditional Chinese Medicine(TCM), Heilongjiang University of Chinese Medicine, Harbin 150040, China
- Publication Type:Research Article
- Keywords:
Liuwei Dihuangwan;
growth and development;
blood metabolism;
metabolic markers;
amino acid metabolism;
3-methoxy-4-(sulfooxy)-benzeneacetic acid;
glycocholic acid
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(12):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The effect of Liuwei Dihuangwan on blood metabolism during growth and development of rats was investigated by taking the overall metabolic profile and biomarkers of metabolomics as indexes. Method: Ultra performance liquid chromatography-high definition mass spectrometry(UPLC-HDMS) was employed to establish a blood metabolomics study method for characterizing the blood metabolic profile of rats at different time before and after administration. The pattern recognition method was used to integrate and analyze the metabolic profiles, and the differential metabolic markers related to drug action were searched. Based on metabolomics pathway analysis(MetPA) and Kyoto encyclopedia of genes and genomes(KEGG) and other databases, the metabolic pathways related to differential markers were analyzed to study the effect of Liuwei Dihuangwan on blood metabolism during growth and development of rats. Result: Liuwei Dihuangwan significantly affect the blood metabolism profiles during growth and development of rats by regulating 30 blood metabolic markers and 12 related target metabolic pathways, and 8 key metabolic markers were delineated. Conclusion: Liuwei Dihuangwan can significantly regulate the blood metabolic network during the growth and development of rats, thereby affecting the growth and development of rats.
