Application of Precise Medication of Xiaoer Fupi Granules for Functional Dyspepsia Based Integrated Pharmacological Strategy
10.13422/j.cnki.syfjx.20190948
- VernacularTitle: 基于整合药理学策略分析小儿扶脾颗粒对功能性消化不良的精准应用
- Author:
Qiong MAN
1
;
Ting-ting WANG
2
;
Chun-yu TANG
3
;
Jun-ying WEI
2
;
Dai-feng TANG
3
;
Hong-jun YANG
2
Author Information
1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
3. Hunan Time Sun Pharmaceutical Co. Ltd., Yongzhou 425007, China
- Publication Type:Research Article
- Keywords:
Xiaoer Fupi granules;
integrated pharmacology;
functional dyspepsia;
precise medicine;
Shenling Baizhusan;
gastrointestinal hormones;
endocrine system
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(11):173-179
- CountryChina
- Language:Chinese
-
Abstract:
Integrated pharmacological approach was used to predict the target genes and signal pathways of Xiaoer Fupi granules in the treatment of functional dyspepsia(FD), and the possible mechanism was discussed. The disease target information was collected by the DISEASES and UniProt databases, integrated pharmacological platform of traditional Chinese medicine(TCM-IP) was used to predict chemical composition, target, protein gene ontology(GO) function and Kyoto encyclopedia of genes and genomes(KEGG) pathway, and the networks of candidate target and TCMs-chemical components-core targets-key pathways were constructed. A total of 2 882 potential targets and 96 candidate target pathways were predicted, and β-1,4-galactosyltransferase(β-1,4-GalT) subtypes(B4GALT4, B4GALT2, B4GALT1) and phosphorylated protein kinase C subtype D(PRKCD), adenylate cyclase 2(ADCY2) and other targets were predicted. Some pathways were enriched, such as nervous system, endocrine system, thyroid hormone signaling pathway, long-term depression and other pathways related to FD. It was predicted that Xiaoer Fupi granules for treating FD by regulating gastrointestinal hormones, anti-depression, and regulating nerves and endocrine system. This study provides a basis for the precise clinical application and positioning of Xiaoer Fupi granules, and helps to clarify the mechanism of this drug.
