Material Basis and Action Mechanism of Wendantang in Treatment of Nervous System Diseases
10.13422/j.cnki.syfjx.20190907
- VernacularTitle: 温胆汤治疗神经系统疾病的物质基础及作用机制研究进展
- Author:
Xi-mei GAO
1
;
Meng JIA
1
;
Yu-mei CHI
1
;
Xiao-li ZHAO
1
;
Hong-zhi QIAO
1
;
Liu-qing DI
1
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
Wendantang;
nervous system diseases;
pharmacodynamic material basis;
action mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(10):188-196
- CountryChina
- Language:Chinese
-
Abstract:
Wendantang (WDT) is a classical traditional Chinese medicine prescription composed of Pinelliae Rhizoma, Bambuseae Caulis in Taenias, Aurantii Fructus Immaturus, Citri Reticulatae Pericarpium, Zingiberis Rhizoma Recens, Glycyrrhizae Radix et Rhizoma, with the effect in regulating Qi-movement and phlegm and relieving stomach and gallbladder. The clinical studies have proved that WDT has significant therapeutic effects on depression, insomnia, schizophrenia, Alzheimer's disease and other nervous system diseases, but wihtout systematic understanding of material basis and compatibility principle because of the complex chemical composition and the scattered research results. Focusing on the neurological diseases and based on the origin of ancient recipes and modern research examples, the author sorted out and summarized the active ingredients constituting the recipe, paid attention to the effect of the compatibility on the composition and efficacy transmission, and judged the rationality of composition intention and selection. On this basis, it comprehensively identifies the potential components and effective paths that can well treat the nervous system diseases, and had the overall understanding about mutual relationship between composition and efficiency. In this article, we expect to find its scientific basis of effective materials and the key technology of quality standards, and define the direction of future research, so as to provide valuable reference for secondary development and new preparations designed of classic prescriptions.
