Clinical Effect of Peiyuan Tongnao Capsule Combined with “Zhisanzhen” for Post-stroke Dementia
10.13422/j.cnki.syfjx.20190931
- VernacularTitle: 培元通脑胶囊联合“智三针”治疗卒中后痴呆的临床观察
- Author:
Cui-lei JIANG
1
;
Jun-jie ZHAO
1
;
Fei LOU
1
;
Ying ZHOU
1
Author Information
1. Laiwu Hospital Affiliated to Taishan Medical University, Laiwu 271100, China
- Publication Type:Research Article
- Keywords:
post-stroke dementia;
Peiyuan Tongnao capsule;
"Zhisanzhen";
Wuhu Zhufeng San;
Dihuang Yinzi;
homocysteine;
hepatocyte growth factor;
acetylcholinase
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):103-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficacy of Peiyuan Tongnao capsule combined with "Zhisanzhen" for post-stroke dementia (PSD) and investigate its mechanism.Method: Ninety-eight eligible patients were randomly divided into control group (49 cases) and observation group (49 cases) by random number table.Both groups received donepezil tablet,10 mg/time,qd,and nimodipine tablet,30 mg/time,qd.Patients in control group additionally took "Zhisanzhen" ,qd,5 times/week.Based on the treatment in control group,patients in observation group additionally took Peiyuan Tongnao capsule,3 capsules/time,tid.The treatment course was 12 weeks.Before and at the 4th,8th and 12th week after treatment,mini-mental state examination (MMSE),montreal cognitive assessment (MoCA),activity of daily living scale (ADL),neuropsychiatric inventory (NPI) and symptoms of traditional Chinese medicine (TCM) were evaluated.Before and after treatment,levels of serum hyperhomocysteinemia (Hcy),hepatocyte growth factor (HGF),oxidized low density lipoprotein (Ox-LDL) and acetylcholinesterase (AchE) were detected.Result: The total clinical effective rate was 93.88% in observation group,better than 77.55% in control group (χ2=5.333,P<0.05).Repeat measurement ANOVA after treatment showed that scores of MoCA,MMSE were gradually increased (Fcontrol=3.947,Fobservation=5.833,P<0.05 for MoCA.Fcontrol=3.876,Fobservation=6.011,P<0.05 for MMSE).At the 8th and 12th after treatment,scores of MMSE in the observation group were all higher than those in control group (P<0.05).At the 12th week after treatment,score of MoCA in observation group was higher than that in control group (P<0.05).Scores of directing force,attention,capacity of calculation in observation group were higher than those in control group after treatment (P<0.05).The changes in scores of MMSE and MoCA in observation group were larger than those in control group after treatment (P<0.05).Scores of ADL,NPI-1,NPI-2 and symptom of TCM in observation group were lower than those in control group (P<0.01).Levels of Hcy,Ox-LDL and AchE were also lower than those in control group,while level of HGF was higher than that in control group (P<0.01).Conclusion: Peiyuan Tongnao capsule combined with "Zhisanzhen" can improve cognitive and behavioral abilities,improve clinical efficacy,ameliorate abnormal mental behavior,relieve clinical symptoms,and regulate levels of Hcy,Ox-LDL,AchE and HGF in the treatment of post-stroke dementia.
