Protective Effect of Phenolic Compound of Osmundae Rhizoma on Systemic Inflammatory Response Syndrome in Mice
10.13422/j.cnki.syfjx.20190909
- VernacularTitle: 紫萁贯众单体成分对小鼠SIRS模型的保护作用
- Author:
Kai LI
1
;
Qing YANG
2
;
Tian-tian ZHOU
2
;
Si-chao YAN
3
;
Xiao-gang WENG
2
;
Lan YANG
2
;
Ying CHEN
2
;
Ya-jie WANG
2
;
Xiao-hui JIANG
1
;
Yuan GUO
3
;
Xiao-xin ZHU
3
;
Yu-jie LI
3
Author Information
1. Anhui University of Chinese Medicine, Hefei 230038, China
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
3. Research Center of Artemisinin, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Research Article
- Keywords:
Osmundae Rhizoma;
systemic inflammatory response syndrome;
endotoxin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):55-60
- CountryChina
- Language:Chinese
-
Abstract:
<Objective: To investigate the protective effect of phenolic compounds 4-hydroxybenzylideneacetone and (HBAc)3,4-dihydroxybenzylideneacetone (DHBAc) of Osmundae Rhizoma on the systemic inflammatory response syndrome (SIRS) in mice by establishing the mice model of SIRS.Method: BALB/c mice were randomly divided into the normal group,the SIRS model group and the different doses of HBAC and DHBAc group (25,50,100 μg·kg-3).Lipopolysaccharides (LPS) was injected intraperitoneally after 7 days of prophylactic administration.After 5 hours of modeling,the anus temperature,respiratory rate,the number of white blood cell (WBC) and platelets (PLT),WBC classification,glycolipid metabolism,inflammatory factor and signal transducing phosphorylated protein of lung were measured.Result: Intraperitoneal injection with LPS (6 mg·kg-1) in mice can significantly reduce the respiratory rate (P<0.05) and the body temperature (P<0.01),decrease the number of WBC,PLT (P<0.01,P<0.01) and blood glucose (P<0.05),and increase the secretion of interleukin-1β(P<0.01).HBAC and DHBAC significantly increased the respiratory rate (P<0.05,P<0.01) and the body temperature (P<0.05,P<0.01) of mice,decreased MONO (P<0.05,P<0.01),and significantly increased the level of blood glucose (P<0.05,P<0.01),and decreased the secretion of interleukin-1β(P<0.01).Conclusion: The SIRS model can be established through intraperitoneal injection of LPS.HBAc and DHBAc have protective effects on endotoxin-induced SIRS in mice,and may exert anti-inflammatory effects through IκB and c-JUN pathways.
