Animal Models of EV71 and CA16 Hand-foot-mouth Disease and Characteristics of Viral Infection
10.13422/j.cnki.syfjx.20190841
- VernacularTitle: EV71和CA16型手足口病动物模型及其病毒感染特点分析
- Author:
Rong-mei YAO
1
;
Xin MAO
1
;
Tian-ge QU
2
;
Shan-shan GUO
1
;
Lei BAO
1
;
Yan-yan BAO
1
;
Xiao-lan CUI
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. School of Basic Medicine Science, Beijing University of Chinese Medicine, Beijing 100029, China
- Publication Type:Research Article
- Keywords:
hand-foot-mouth disease;
enterovirus 71;
coxsackie virus A16;
animal models;
characteristics of virus infection
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(8):172-180
- CountryChina
- Language:Chinese
-
Abstract:
Hand-foot-mouth disease (HFMD) is a common infectious disease caused by enterovirus in children. It has a high incidence and can cause fatal complications such as pulmonary edema, myocarditis and aseptic meningitis, seriously threatening the health of children. At present, some core problems such as the pathogenesis of disease, the relationship between different genotypes of pathogenic viruses, the pharmacodynamic evaluation methods, and the antiviral mechanism of drugs are still unclear. The construction of disease animal models with simulation performance of human exposure is the key to solve the above problems. Researchers both at home and abroad have established a variety of animal models for HFMD, of which enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are most common and most widely used. Both EV71 and CA16 are enterovirus A in picornavirus family, so they have similarities in terms of pathogenicity, infection and replication characteristics, clinical symptoms caused by infection and immune response, but also have significant differences in age of susceptibility, method of infection, as well as neurotoxicity, clinical symptoms and signs, and degree of tissue and organ damage. Therefore, researchers shall select and establish proper animal models based on actual conditions, which is critical to the reliability of the results. In this paper, the different types of HFMD animal models established by EV71 and CA16 viruses were reviewed, especially on the species strains, virus strain types, infection methods, and characteristics of viral infections in each model, and the characteristics and clinical symptoms of HFMD induced by EV71 and CA16 were also investigated to provide reference for related research.
